Mammalian ceramide synthases
نویسندگان
چکیده
منابع مشابه
Ceramide synthases at the centre of sphingolipid metabolism and biology.
Sphingolipid metabolism in metazoan cells consists of a complex interconnected web of numerous enzymes, metabolites and modes of regulation. At the centre of sphingolipid metabolism reside CerSs (ceramide synthases), a group of enzymes that catalyse the formation of ceramides from sphingoid base and acyl-CoA substrates. From a metabolic perspective, these enzymes occupy a unique niche in that t...
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Ceramide is the key intermediate in the pathway of sphingolipid (SL) biosynthesis (1) and an important intracellular signaling molecule (2,3). Ceramide consists of a sphingoid long chain base to which a fatty acid is attached via an amide bond (Fig. 1). When the chemical composition of SLs was first determined in the 1940s (4), stearic acid (C18:0) was identified as the major fatty acid attache...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2010
ISSN: 1521-6543,1521-6551
DOI: 10.1002/iub.319